期刊
IMMUNOLOGICAL REVIEWS
卷 264, 期 1, 页码 319-326出版社
WILEY
DOI: 10.1111/imr.12256
关键词
intraphagosomal nutrients; mycobacterial stress resistance; attenuated Mtb mutants
类别
资金
- National Institutes of Health [R01 AI63446, R01 AI092573, R01 AI09179]
- Bill and Melinda Gates Foundation [42848, OPP1024065, OPP1024050, OPP1068025]
- Burroughs Wellcome Career Award in the Biomedical Sciences
- Bill and Melinda Gates Foundation [OPP1024065, OPP1068025, OPP1024050] Funding Source: Bill and Melinda Gates Foundation
Mycobacterium tuberculosis (Mtb) has evolved within the human immune system as both host and reservoir. The study of genes required for its growth and persistence in vivo thus offers linked insights into its pathogenicity and host immunity. Studies of Mtb mutants have implicated metabolic adaptation (consisting of carbon, nitrogen, vitamin, and cofactor metabolism), intrabacterial pH homeostasis, and defense against reactive oxygen and reactive nitrogen species, as key determinants of its pathogenicity. However, the mechanisms of host immunity are complex and often combinatorial. Growing evidence has thus begun to reveal that the determinants of Mtb's pathogenicity may serve a broader and more complex array of functions than the isolated experimental settings in which they were initially found. Here, we review select examples, which exemplify this complexity, highlighting the distinct phases of Mtb's life cycle and the diverse microenvironments encountered therein.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据