期刊
IMMUNOLOGICAL REVIEWS
卷 264, 期 1, 页码 154-166出版社
WILEY
DOI: 10.1111/imr.12271
关键词
MR1; mucosal associated invariant T cells (MAIT); tuberculosis
类别
资金
- National Institutes of Health (NIH) [AI078965, AI48090]
- Mucosal Immunology Studies Team (MIST) - National Institute of Allergy and Infectious Diseases [U01 AI095776-01]
The intracellular pathogen Mycobacterium tuberculosis (Mtb) and its human host have long co-evolved. Although the host cellular immune response is critical to the control of the bacterium information on the specific contribution of different immune cell subsets in humans is incomplete. Mucosal associated invariant T (MAIT) cells are a prevalent and unique T-cell population in humans with the capacity to detect intracellular infection with bacteria including Mtb. MAIT cells detect bacterially derived metabolites presented by the evolutionarily conserved major histocompatibility complex-like molecule MR1. Here, we review recent advances in our understanding of this T-cell subset and address the potential roles for MR1-restricted T cells in the control, diagnosis, and therapy of tuberculosis.
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