期刊
ACS APPLIED MATERIALS & INTERFACES
卷 6, 期 2, 页码 1082-1091出版社
AMER CHEMICAL SOC
DOI: 10.1021/am404627r
关键词
clay scaffold; 3D scaffold; tissue engineering; electrospinning; cellular infiltration; selective leaching
资金
- National Research Foundation (NRF)
- Korean Government (MSIP) through the Active Polymer Center Pattern Integration [2007-0056091]
- Basic Science Research Program [2012R1A1A1003397]
- Ministry of Science, ICT & Future Planning (MSIP)
The development of three-dimensional polymeric systems capable of mimicking the extracellular matrix is critical for advancing tissue engineering. To achieve these objectives, three-dimensional fibrous scaffolds with clay-like properties were successfully developed by coaxially electrospinning polystyrene (PS) and poly(epsilon-caprolactone) (PCL) and selective leaching. As PS is known to be nonbiodegradable and vulnerable to mechanical stress, PS layers present at the outer surface were removed using a selective leaching process. The fibrous PCL scaffolds that remained after the leaching step exhibited highly advantageous characteristics as a tissue engineering scaffold, including moldability (i.e., clay-like), flexibility, and three-dimensional structure (i.e., cotton-like). More so, the clay-like PCL fibrous scaffolds could be shaped into any desired form, and the microenvironment within the clay scaffolds was highly favorable for cell expansion both in vitro and in vivo. These electrospun-clay scaffolds overcome the current limitations of conventional electrospun, sheet-like scaffolds, which are structurally inflexible. Therefore, this work extends the scope of electrospun fibrous scaffolds toward a variety of tissue engineering applications.
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