期刊
IMMUNOLOGICAL REVIEWS
卷 268, 期 1, 页码 6-24出版社
WILEY
DOI: 10.1111/imr.12341
关键词
Fc receptors; genetics; immunotherapy; antibodies
类别
资金
- Experimental Cancer Medicine Centre (ECMC)
- Leukaemia and Lymphoma Research [11052, 12050]
- Wellcome Trust [087663]
- United Kingdom National Centre for the Replacement, Refinement and Reduction of Animals in Research CRACK IT Programme [NC/C011204/1]
- Kay Kendall Leukaemia Fund [KKL687]
- Uehara Memorial Foundation
- Roche
- GSK biopharm
- Pfizer, Inc.
Fc receptors (FcRs) are key immune receptors responsible for the effective control of both humoral and innate immunity and are central to maintaining the balance between generating appropriate responses to infection and preventing autoimmunity. When this balance is lost, pathology results in increased susceptibility to cancer, autoimmunity, and infection. In contrast, optimal FcR engagement facilitates effective disease resolution and response to monoclonal antibody immunotherapy. The underlying genetics of the FcR gene family are a central component of this careful balance. Complex in humans and generated through ancestral duplication events, here we review the evolution of the gene family in mammals, the potential importance of copy number, and functionally relevant single nucleotide polymorphisms, as well as discussing current approaches and limitations when exploring genetic variation in this region.
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