期刊
ACS APPLIED MATERIALS & INTERFACES
卷 6, 期 20, 页码 17323-17345出版社
AMER CHEMICAL SOC
DOI: 10.1021/am5045604
关键词
polymeric nanoarchitecture; antibacterial properties; biomedical implants; titanium; surface modification
资金
- National Science Fund for Excellent Young Scholars [51422102]
- NSFC [51101053, 81271715]
- Hong Kong Research Grants Council (RGC) General Research Funds (GRF) [112212]
- City University of Hong Kong Applied Research Grant (ARG) [9667085]
- Excellent Youth Foundation of the Hubei Scientific Committee [2013CFA018]
Because of the excellent mechanical properties and good biocompatibility, titanium-based metals are widely used in hard tissue repair, especially load-bearing orthopedic applications. However, bacterial infection and complication during and after surgery often causes failure of the metallic implants. To endow titanium-based implants with antibacterial properties, surface modification is one of the effective strategies. Possessing the unique organic structure composed of molecular and functional groups resembling those of natural organisms, functionalized polymeric nanoarchitectures enhance not only the antibacterial performance but also other biological functions that are difficult to accomplish on many conventional bioinert metallic implants. In this review, recent advance in functionalized polymeric nanoarchitectures and the associated antimicrobial mechanisms are reviewed.
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