期刊
ACS APPLIED MATERIALS & INTERFACES
卷 6, 期 20, 页码 17985-17992出版社
AMER CHEMICAL SOC
DOI: 10.1021/am504816h
关键词
albumin; nanocomplex; near-infrared; photoacoustic tomography; red shift; squaraine dye
资金
- National Natural Science Foundation of China [91027021, 81171455, 61078073, 31225009]
- National Basic Research Program of China [2013CB933500, 2011CB808400, 2012CB932400, 2011CB707502]
Photoacoustic tomography (PAT) is a newly emerging noninvasive imaging modality that could be further enhanced using near-infrared (NIR)-absorbing materials as contrast agents. To date, the most extensively studied photoacoustic imaging agents are inorganic nanomaterials because organic materials with NIR-absorption capabilities are limited. In this study, a NIR-absorbing nanocomplex composed of a squaraine dye (SQ) and albumin was prepared based on the aggregation-induced NIR absorption of SQ. Through aggregation, the absorption spectrum of SQ was widened from the visible-light region to the NIR region, which facilitated photoacoustic signal generation in the tissue-transparent NIR optical window (700-900 nm). Blood analysis and histology measurements revealed that the nanocomplex can be used for PAT applications in vivo without obvious toxicity to living mice.
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