期刊
ACS APPLIED MATERIALS & INTERFACES
卷 6, 期 10, 页码 7038-7044出版社
AMER CHEMICAL SOC
DOI: 10.1021/am502046h
关键词
alloy micropattern; electrospinning; nanofiber micropattern; hydrogel; cell encapsulation
资金
- American Diabetes Association [7-13-JF-42, 1-12-JF-06]
- National Science Foundation [ECCS-0335765]
- NSF MRSEC program [DMR-1120296]
- New York Stem Cell Foundation [R-103]
- NIH [DP2 DK 98093 01]
- Tri-Institutional Starr Stem Cell Postdoctoral Fellowship
A simple, robust, and cost-effective method is developed to fabricate nanofibrous micropatterns particularly microposts and microwells of controlled shapes. The key to this method is the use of an easily micropatternable and intrinsically conductive metal alloy as a template to collect electrospun fibers. The micropatterned alloy allows conformal fiber deposition with high fidelity on its topographical features and in situ formation of diverse, free-standing micropatterned nanofibrous membranes. Interestingly, these membranes can serve as structural frames to form robust hydrogel micropatterns that may otherwise be fragile on their own. These hybrid micropatterns represent a new platform for cell encapsulation where the nanofiber frames enhance the mechanical integrity of hydrogel and the micropatterns provide additional surface area for mass transfer and cell loading.
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