Antibiotic sensitivity profile of bacterial pathogens in postoperative wound infections at a tertiary care hospital in Gujarat, India

Objective: To fi nd out the most common bacterial pathogens responsible for post-operative wound infection and their antibiotic sensitivity profi le. Materials and Methods: This prospective, observational study was carried out in patients of postoperative wound infection. Samples from wound discharge were collected using a sterile swab and studied for identifi cation of isolates by Gram stains and culture growth followed by in vitro antibiotic susceptibility testing performed by disc diffusion method on Mueller Hinton agar. Results: Out of 183 organisms, 126 (68.85%) isolated organisms were gram negative. Staphylococcus aureus, 48 (26.23%), was the predominant organism. S. aureus was sensitive to rifampicin (89.58%), levofl oxacin (60.42%), and vancomycin (54.17%). Pseudomonas aeruginosa was sensitive to ciprofl oxacin (83.78%), gatifl oxacin (51.35%), and meropenem (51.35%). Escherichia coli was sensitive to levofl oxacin (72.41%) and ciprofl oxacin (62.07%). Klebsiella pneumoniae was sensitive to ciprofl oxacin (63.16%), levofl oxacin (63.16%), gatifl oxacin (63.16%), and linezolid (56.52%). Proteus mirabilis was sensitive to ciprofl oxacin (75%) and linezolid (62.50). Proteus vulgaris was sensitive to ampicillin+ sulbactam (57.14%) followed by levofl oxacin (50%). Conclusions: There is an alarming increase of infections caused by antibiotic-resistant bacteria, particularly in the emergence of VRSA/ VISA, meropenem, and third generation cephalosporin resistant Pseudomonas aeruginosa. Linezolid showing sensitivity against Gram negative bacteria.