期刊
ACS APPLIED MATERIALS & INTERFACES
卷 5, 期 24, 页码 13325-13332出版社
AMER CHEMICAL SOC
DOI: 10.1021/am404292e
关键词
graphene oxide; MR imaging; contrast agents; cellular imaging; theranostics
资金
- National Natural Science Foundation of China [51361130033, 21205129, 81171393, 31271066]
- Chinese Academy of Sciences
Magnetic resonance imaging (MRI) is a powerful and widely used clinical technique in cancer diagnosis. MRI contrast agents (CAs) are often used to improve the quality of MRI-based diagnosis. In this work, we developed a positive T-1 MRI CA based on graphene oxide (GO)-gadolinium (Gd) complexes. In our strategy, diethylenetriaminepentaacetic acid (DTPA) is chemically conjugated to GO, followed by Gd(III) complexation, to form a T-1 MRI CA (GO-DTPA-Gd). We have demonstrated that the GO-DTPA-Gd system significantly improves MRI T-1 relaxivity and leads to a better cellular MRI contrast effect than Magnevist, a commercially used CA. Next, an anticancer drug, doxorubicin (DOX), was loaded on the surface of GO sheets via physisorption. Thus-prepared GO-DTPA-Gd/DOX shows significant cytotoxicity to the cancer cells (HepG2). This work provides a novel strategy to build a GO-based theranostic nanoplatform with T-1-weighted MM, fluorescence imaging, and drug delivery functionalities.
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