期刊
ACS APPLIED MATERIALS & INTERFACES
卷 5, 期 11, 页码 4966-4971出版社
AMER CHEMICAL SOC
DOI: 10.1021/am400721s
关键词
magnetic cores; gold nanoshells; magnetic resonance imaging (MRI); dark field imaging (DFI); photothermal therapy
资金
- National Natural Science Foundation of China [81171454, 31271075, 81000667, 81201814]
- Beijing Nova Program [Z111103054511113]
Merging different components into a single nanoparticle can exhibit profound impact on various biomedical applications including diagnostics, imaging, and therapy. However, retaining the unique properties of each component after integration has proven to be a significant challenge. Our previous research demonstrated that gold nanoshells on polystyrene spheres have potential in photohermal therapy. Here, we report a facile and green strategy to synthesize a multifunctional nanocomposite with Fe3O4 core coated gold nanoshells as dual imaging probes and photothermal agents. The as prepared nanoparticles exhibit well-defined structure and excellent physical properties such as magnetic and plasmonic activities. Therefore, they were applied as contrast agents in magnetic resonance imaging (MRI) and dark field imaging (DFI). Besides, we demonstrated their potential application in photothermal therapy. Moreover, the obtained multifunctional nanoparticles have shown excellent biocompatibility for their low cytotoxicity and hemolyticity.
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