期刊
ACS APPLIED MATERIALS & INTERFACES
卷 4, 期 10, 页码 5317-5324出版社
AMER CHEMICAL SOC
DOI: 10.1021/am301258a
关键词
self-assembly; supramolecular microcapsules; pH-responsive; drug controlled release
资金
- Ministry of Science and Technology of China [2011CB606202]
- National Natural Science Funds for Distinguished Young scholar [51125014]
- Research Fund for the Doctoral Program of Education of China
- Planning Project of Innovative Experiment of National Undergraduate [091048617]
Supramolecular microcapsules (SMCs) with the drug-loaded wall layers for pH-controlled drug delivery were designed and prepared. By using layer-by-layer (LbL) technique, the SMCs were constructed based on the self-assembly between polyaldenhyde dextran-graft-adamantane (PAD-g-AD) and carboxymethyl dextran-graft-beta-CD (CMD-g-beta-CD) on CaCO3 particles via host-guest interaction. Simultaneously, adamantine-modified doxorubicin (AD-Dox) was also loaded on the LbL wall via host-guest interaction. The in vitro drug release study was carried out at different pHs. Because the AD groups were linked with PAD (PAD-g-AD) or Dox (AD-Dox) by pH-cleavable hydrazone bonds, AD moieties can be removed under the weak acidic condition, leading to destruction of SMCs and release of Dox. The pH-controlled drug release can enhance the uptake by tumor cells and thus achieve improved cancer therapy efficiency.
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