期刊
ACS APPLIED MATERIALS & INTERFACES
卷 4, 期 8, 页码 4312-4319出版社
AMER CHEMICAL SOC
DOI: 10.1021/am300983u
关键词
single walled carbon nanotube; gold nanoparticle; supramolecular assembly; enzyme biosensor; cyclodextrin
资金
- Spanish Ministry of Science and Innovation
- Spanish Ministry of Science and Innovation [CTQ2011-24355, CTQ2009-12650, CTQ2009-09351]
- Comunidad de Madrid [S2009/PPQ-1642]
Glassy carbon electrodes modified with single-walled carbon nanotubes and a three-dimensional network of electropolymerized Au nanoparticles capped with 2-mercaptoethanesulfonic acid, p-aminothiophenol, and 1-adamantanethiol were used as hybrid electrochemical platforms for supramolecular immobilization of a synthesized artificial neoglycoenzyme of xanthine oxidase and beta-cyclodextrin through host-guest interactions. The ensemble was further employed for the bioelectrochemical determination of xanthine. The biosensor showed fast amperometric response within 5 s and a linear behavior in the 50 nM to 9.5 mu M xanthine concentration range with high sensitivity, 2.47 A/(M cm(2)), and very low, detection limit of 40 nM. The stability of the biosensor was significantly improved and the interferences caused by ascorbic and uric acids were noticeably minimized by coating the electrode surface with a Nafion thin film.
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