期刊
ACS APPLIED MATERIALS & INTERFACES
卷 4, 期 4, 页码 1865-1871出版社
AMER CHEMICAL SOC
DOI: 10.1021/am300177t
关键词
heterofunctional proteins; hierarchical assemblies; ferroelectric LiNbO3 substrate; photochemical deposition; protein microarrays; biological-material interface
资金
- National Science Foundation through the NSF-MRSEC at the Genetically Engineered Materials Science and Engineering Center (GEMSEC) [DMR 0520567]
- TUBITAK/NSF-IRES
- NSF through BMAT at the University of Washington [DMR-0706655]
- World Premier Institute Initiative for Materials Nanoarchitectonics (MANA) in the National Institute for Materials Science, Japan
- ARO DURIP [W911NF-08-01-0262]
This study demonstrates a biological route to programming well-defined protein-inorganic interfaces with an arrayed geometry via modular peptide tag technology. To illustrate this concept, we designed a model multifunctional fusion protein, which simultaneously displays a maltose-binding protein (MBP), a green fluorescence protein (GFPuv) and an inorganic-binding peptide (AgBP2C). The fused combinatorially selected AgBP2C tag controls and site-directs the multifunctional fusion protein to immobilize on silver nanoparticle arrays that are fabricated on specific domain surfaces of ferroelectric LiNbO3 via photochemical deposition and in situ synthesis. Our combined peptide-assisted biological and ferroelectric lithography approach offers modular design and versatility in tailoring surface reactivity for fabrication of nanoscale devices in environmentally benign conditions.
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