期刊
IMMUNOBIOLOGY
卷 220, 期 2, 页码 280-294出版社
ELSEVIER GMBH, URBAN & FISCHER VERLAG
DOI: 10.1016/j.imbio.2014.09.010
关键词
Macrophage; Iron; Infection; Nutritional immunity; Anemia of inflammation; Anemia of chronic disease
类别
资金
- Austrian Research Funds (FWF) [TRP-188]
- EU-7th framework (EUROCALIN)
- Medical University of Innsbruck
- Verein zur Forderung von Forschung und Weiterbildung in Infektiologie und Immunologie an der Medizinischen Universitat Innsbruck
Iron homeostasis and macrophage biology are closely interconnected. On the one hand, iron exerts multiple effects on macrophage polarization and functionality. On the other hand, macrophages are central for mammalian iron homeostasis. The phagocytosis of senescent erythrocytes and their degradation by macrophages enable efficient recycling of iron and the maintenance of systemic iron balance. Macrophages express multiple molecules and proteins for the acquisition and utilization of iron and many of these pathways are affected by inflammatory signals. Of note, iron availability within macrophages has significant effects on immune effector functions and metabolic pathways within these cells. This review summarizes the physiological and pathophysiological aspects of macrophage iron metabolism and highlights its relevant consequences on immune function and in common diseases such as infection and atherosclerosis. (C) 2014 Elsevier GmbH. All rights reserved.
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