期刊
ACS APPLIED MATERIALS & INTERFACES
卷 4, 期 1, 页码 142-149出版社
AMER CHEMICAL SOC
DOI: 10.1021/am201166m
关键词
magnetite nanoparticles; polyethyleneglycol-coating; soft magnetic nanomaterials; protein-nanoparticle interaction
资金
- Department of Science and Technology (DST), Government of India [SR/S5/NM-17/2006]
- CSIR [OLP004]
We report here a facile and green synthetic approach to prepare magnetite (Fe3O4) nanoparticles (NPs) with magnetic core and polyethylene glycol (PEG) surface coating. The interaction of the bare and PEG-coated Fe3O4 NPs with cytochrome c (cyt c, an important protein with direct role in the electron transfer chain) is also reported in this study. With ultrasonication as the only peptization method and water as the synthesis medium, this method is easy, fast, and environmentally benign. The PEG coated NPs are highly water dispersible and stable. The bare NPs have considerable magnetism at room temperature; surface modification by PEG has resulted in softening the magnetization. This approach can very well be applicable to prepare biocompatible, surface-modified soft magnetic materials, which may offer enormous utility in the field of biomedical research. Detailed characterizations including XRD, FTIR, TG/DTA, TEM, and VSM of the PEG-coated Fe3O4 NPs were carried out in order to ensure the future applicability of this method. Although the interaction of bare NPs with cyt c shows reduction of the protein, efficient surface modification by PEG prevents its reduction.
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