期刊
NATURE REVIEWS CANCER
卷 11, 期 7, 页码 523-532出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3081
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资金
- US National Institutes of Health [U54-CA149147, R01-GM078989]
- US National Science Foundation [DMS-0342283, DBI-0904340]
- Virginia Polytechnic Institute
- State University graduate program in Genetics, Bioinformatics and Computational Biology
- Direct For Biological Sciences
- Div Of Biological Infrastructure [0904340] Funding Source: National Science Foundation
Cancers of the breast and other tissues arise from aberrant decision-making by cells regarding their survival or death, proliferation or quiescence, damage repair or bypass. These decisions are made by molecular signalling networks that process information from outside and from within the breast cancer cell and initiate responses that determine the cell's survival and reproduction. Because the molecular logic of these circuits is difficult to comprehend by intuitive reasoning alone, we present some preliminary mathematical models of the basic decision circuits in breast cancer cells that may aid our understanding of their susceptibility or resistance to endocrine therapy.
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