期刊
IMMUNOBIOLOGY
卷 220, 期 2, 页码 249-253出版社
ELSEVIER GMBH
DOI: 10.1016/j.imbio.2014.10.001
关键词
Cancer-related inflammation; Chemokine; Myeloid cells; Myeloid-derived suppressor cells; Tumor-associated macrophages; Tumor-associated neutrophils
类别
资金
- Ministero dell'Istruzione dell'Universita e della Ricerca (FIRB projects) [RBFR08CW8G, RBAP11H2R9]
- Ministero della Salute (Giovani Ricercatori) [GR-2008-1138226]
- Italian Association for Cancer Research (AIRC: IG) [14685]
- European Community's Seventh Framework Program [FP7] [HEALTH-F4-2011-281608]
Myeloid cells are key elements of the cancer-related inflammation with the potential to support not only tumor growth but also invasion and metastasis. Tumor-derived factors affect myeloid cell differentiation inducing a phenotype that supports tumor growth, inducing immunosuppression, angiogenesis and tissue remodeling. Soluble mediators, produced at primary tumor site, can also act in a remote mode inducing the release from bone marrow of myeloid cells that have immunosuppressive activities in tumor-draining lymphoid organs and can predispose to colonization when migrate to metastatic organs. We will here review current knowledge on the contribution of tumor-derived signals that affect polarized activation of myeloid cells, their bone marrow release and recruitment to metastatic sites with a particular focus on the role of chemokines. (C) 2014 Elsevier GmbH. All rights reserved.
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