期刊
ACS APPLIED MATERIALS & INTERFACES
卷 3, 期 8, 页码 2895-2903出版社
AMER CHEMICAL SOC
DOI: 10.1021/am200576q
关键词
polyurethane; tubing; surface grafting; N-halamine; biofilm-controlling; rechargeable
资金
- NIH, NIDCR [R01DE018707]
- EPSCoR
- Office Of The Director [0903804] Funding Source: National Science Foundation
A simple and practical surface grafting approach was developed to introduce rechargeable N-halamine-based antimicrobial functionality onto the inner surfaces of continuous small-bore polyurethane (PU) dental unit waterline (DUWL) tubing. In this approach, tetrahydrofuran (THF) solution of a free-radical initiator, dicumyl peroxide (DCP), flowed through the PU tubing (inner diameter of 1/16 in., or 1.6 mm) to diffuse DCP into the tubing's inner walls, which was used as initiator in the subsequent grafting polymerization methacrylamide (MAA) onto the tubing. Upon chlorine bleach treatment, the amide groups of the grafted MAA side chains were transformed into acyclic N-halamines. The reactions were confirmed with attenuated total reflectance infrared (ATR) spectra and iodometric titration. The mechanical properties of the tubing were not significantly affected by the grafting reactions. The biofilm-controlling function of the new N-halamine-based PU tubing Was evaluated with Pseudomonas aeruginosa (P. aeruginosa), one of the most isolated water bacteria from DUWLs, in a continuous bacterial., flow, model. Bacteria culturing and SEM studies showed that the inner surfaces of the new N-halaniine-based PU tubing completely prevented bacterial biofilm formation for at least three to four weeks. After that, bacteria began to colonize the tubing surface: However, the lost function was fully regenerated by exposing the tubing inner surfaces to diluted chlorine bleach The recharging process could be repeated periodically to further extend the biofilm-controlling duration for long-term applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据