期刊
IMMUNITY
卷 42, 期 6, 页码 991-1004出版社
CELL PRESS
DOI: 10.1016/j.immuni.2015.06.003
关键词
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类别
资金
- Fund for Scientific Research Flanders (FWO) [G028712N, G046612N, G016413N, G027413N, G090914N]
- Belgian Foundation Against Cancer
- Agency for Innovation by Science and Technology
- Interuniversity Attraction Poles [P7/32]
- Belgian Science Policy (Belgian Coordinated Collections of Microorganisms [BCCM]/LMBP)
- Ghent University [BOF13-GOA-005]
- FWO
- IWT
Members of the extended interleukin-1 (IL-1) cytokine family, such as IL-1, IL-18, IL-33, and IL-36, play a pivotal role in the initiation and amplification of immune responses. However, deregulated production and/or activation of these cytokines can lead to the development of multiple inflammatory disorders. IL-1 family members share a broadly similar domain organization and receptor signaling pathways. Another striking similarity between IL-1 family members is the requirement for proteolytic processing in order to unlock their full biological potential. Although much emphasis has been put on the role of caspase-1, another emerging theme is the involvement of neutrophil-and mast cell-derived proteases in IL-1 family cytokine processing. Elucidating the regulation of IL-1 family members by proteolytic processing is of great interest for understanding inflammation and immunity. Here, we review the identity of the proteases involved in the proteolytic processing of IL-1 family cytokines and the therapeutic implications in inflammatory disease.
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