期刊
ACS APPLIED MATERIALS & INTERFACES
卷 2, 期 3, 页码 768-773出版社
AMER CHEMICAL SOC
DOI: 10.1021/am900784a
关键词
organic-inorganic hybrid; drug delivery system; hollow capsule; lipid bilayer; layer-by-layer assembly
资金
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan [20686046, 2008-2009]
- Grants-in-Aid for Scientific Research [20686046] Funding Source: KAKEN
Magnetoresponsive smart capsules formed with polyelectrolyres, lipid bilayers and magnetic nanoparticles were fabricated by a colloid-templating technique. Melamine-formaldehyde core particles with polyelectrolyte multilayer shell were prepared by layer-by-layer assembly. magnetite (Fe3O4) nanoparticles were selectively deposited on the capsular surface by aqueous solution deposition using Pd catalysts. Hollow capsules were obtained by the removal of the melamine formaldehyde core particles. Vibrating sample magnetometer (VSM) measurement of the capsules revealed the ferromagnetic behavior of deposited Fe3O4 nanoparticles. Alternating magnetic field irradiation generates heat in the capsular dispersion. Additional lipid bilayer coating was carried out on the obtained hollow capsules. Dye molecules were loaded by exploiting the temperature-dependence of the lipid membrane permeability. An encapsulated dye was released on-demand by irradiation with an alternating magnetic held, due to a phase transition in the lipid membrane, induced by heating of the magnetic nanoparticles. The magnetically induced release is attributed to the phase transition of the lipid membrane, caused by heat of Fe3O4 nanoparticles under magnetic stimuli, and not to rupture of the capsules.
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