期刊
IMMUNITY
卷 43, 期 2, 页码 318-330出版社
CELL PRESS
DOI: 10.1016/j.immuni.2015.07.015
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资金
- Mechanisms for the Development of Allergy (MeDALL), a Seventh Framework Program (FP7) of the European Union
- National Health and Medical Research Council of Australia [1054925]
- ERC consolidator grant
- University of Gent GROUP-ID MRP grant
- Swedish Research Council Young Investigator Grant
- FWO grants
Asthma is a T helper 2 (Th2)-cell-mediated disease; however, recent findings implicate Th17 and innate lymphoid cells also in regulating airway inflammation. Herein, we have demonstrated profound interleukin-21 (IL-21) production after house dust mite (HDM)-driven asthma by using T cell receptor (TCR) transgenic mice reactive to Dermatophagoides pteronyssinus 1 and an IL-21GFP reporter mouse. IL-21-producing cells in the mediastinal lymph node (mLN) bore characteristics of T follicular helper (Tfh) cells, whereas IL-21(+) cells in the lung did not express CXCR5 (a chemokine receptor expressed by Tfh cells) and were distinct from effector Th2 or Th17 cells. Il21r(-/-) mice developed reduced type 2 responses and the IL-21 receptor (IL-21R) enhanced Th2 cell function in a cell-intrinsic manner. Finally, administration of recombinant IL-21 and IL-25 synergistically promoted airway eosinophilia primarily via effects on CD4(+) lymphocytes. This highlights an important Th2-cell-amplifying function of IL-21-producing CD4(+) T cells in allergic airway inflammation.
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