期刊
IMMUNITY
卷 43, 期 3, 页码 421-434出版社
CELL PRESS
DOI: 10.1016/j.immuni.2015.08.023
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资金
- Telethon Foundation [GGP13002]
- UNIMI Piano di Ricerca B
- Ministero della Salute [WFR GR-2011-02346974]
- ANR-France
- EU FP7 program
- Deutsche Forschungsgemeinschaft [CH279/5-1]
- ERC (ENDHOMRET)
- ERC [310496]
- Fondazione Italiana Sclerosi Multipla (FISM) [2012/R/11]
- ERC Consolidator Grant [310372]
- INSERM
- Region Ile de France (CORDDIM)
- Fondation de la Recherche Medicale (FRM)
- Fondation de France (FdF)
- Science Foundation Ireland
- British Heart Foundation [RG/14/2/30616]
- Bill and Melinda Gates Foundation [OPP1043517]
- British Heart Foundation [RG/14/2/30616] Funding Source: researchfish
- European Research Council (ERC) [310496] Funding Source: European Research Council (ERC)
- Bill and Melinda Gates Foundation [OPP1043517] Funding Source: Bill and Melinda Gates Foundation
The immune response requires major changes to metabolic processes, and indeed, energy metabolism and functional activation are fully integrated in immune cells to determine their ability to divide, differentiate, and carry out effector functions. Immune cell metabolism has therefore become an attractive target area for therapeutic purposes. A neglected aspect in the translation of immunometabolism is the critical connection between systemic and cellular metabolism. Here, we discuss the importance of understanding and manipulating the integration of systemic and immune cell metabolism through in-depth analysis of immune cell phenotype and function in human metabolic diseases and, in parallel, of the effects of conventional metabolic drugs on immune cell differentiation and function. We examine how the recent identification of selective metabolic programs operating in distinct immune cell subsets and functions has the potential to deliver tools for cell- and function-specific immunometabolic targeting.
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