期刊
ACS APPLIED MATERIALS & INTERFACES
卷 2, 期 6, 页码 1737-1742出版社
AMER CHEMICAL SOC
DOI: 10.1021/am1002316
关键词
PIXE-RBS methods; biomaterials; bioactive glass; sol-gel
资金
- Foundation for Polish Science
- Conseil Regional d'Auvergne
In this work, the physicochemical reactions occurring at the surface of bioactive sol gel derived 3D glass scaffolds via a complete PIXE characterization were studied. 3D glass foams in the SiO2-CaO system were prepared by sol gel route. Samples of glass scaffolds were soaked in biological fluids for periods up to 2 days. The surface changes were characterized using particle induced X-ray emission (PIXE) associated to Rutherford backscattering spectroscopy (RBS), which are efficient methods to perform quantitative chemical maps. Elemental maps of major and trace elements at the glass/biological fluids interface were obtained at the micrometer scale for every interaction time Results revealed interconnected macropores and physicochemical reactions occurring at the surface of pores. The micro-PIXE-RBS characterization or the pores/biological fluids interface shows the glass dissolution and the rapid formation of a Ca rich layer with the presence of phosphorus that came from biological fluids. After 2 days, a calcium phosphate rich layer containing magnesium is formed at the surface of the glass scaffolds. We demonstrate that quantities of phosphorus provided only by the biological Medium have a significant impact on the development and-the:formation of the phosphocalcic layer.
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