期刊
IMMUNITY
卷 43, 期 3, 页码 527-540出版社
CELL PRESS
DOI: 10.1016/j.immuni.2015.08.011
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资金
- European Research Council (Dendroworld, HomeoGUT)
- Italian Association for Cancer Research (AIRC)
- Italian Ministry of Health (Ricerca finalizzata)
- Italian Ministry of Education, University and Research [PON01_02589]
- Consiglio Nazionale delle Ricerche of Italy (progetto strategico Medicina personalizzata)
- Marie Curie program (Sipod)
- Fondazione Umberto Veronesi (FUV)
- AIRC fellowships
The interrelationship between IgAs and microbiota diversity is still unclear. Here we show that BALB/c mice had higher abundance and diversity of IgAs than C57BL/6 mice and that this correlated with increased microbiota diversity. We show that polyreactive IgAs mediated the entrance of non-invasive bacteria to Peyer's patches, independently of CX3CR1(+) phagocytes. This allowed the induction of bacteria-specific IgA and the establishment of a positive feedback loop of IgA production. Cohousing of mice or fecal transplantation had little or no influence on IgA production and had only partial impact on microbiota composition. Germ-free BALB/c, but not C57BL/6, mice already had polyreactive IgAs that influenced microbiota diversity and selection after colonization. Together, these data suggest that genetic predisposition to produce polyreactive IgAs has a strong impact on the generation of antigenspecific IgAs and the selection and maintenance of microbiota diversity.
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