期刊
IMMUNITY
卷 42, 期 2, 页码 279-293出版社
CELL PRESS
DOI: 10.1016/j.immuni.2015.01.015
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资金
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Science and Technology Agency
- Ministry of Health, Labour and Welfare
- Grants-in-Aid for Scientific Research [24111005, 24390093, 26893047] Funding Source: KAKEN
Crosslinking of the immunoglobulin receptor Fc epsilon RI activates basophils and mast cells to induce immediate and chronic allergic inflammation. However, it remains unclear how the chronic allergic inflammation is regulated. Here, we showed that ecto-nucleotide pyrophosphatase-phosphodiesterase 3 ( E-NPP3), also known as CD203c, rapidly induced by Fc epsilon RI crosslinking, negatively regulated chronic allergic inflammation. Basophil and mast cell numbers increased in Enpp3(-/-) mice with augmented serum ATP concentrations. Enpp3(-/-) mice were highly sensitive to chronic allergic pathologies, which was reduced by ATP blockade. Fc epsilon RI crosslinking induced ATP secretion from basophils and mast cells, and ATP activated both cells. ATP clearance was impaired in Enpp3(-/-) cells. Enpp3(-/-) P2rx7(-/-) mice showed decreased responses to FceRI crosslinking. Thus, ATP released by Fc epsilon RI crosslinking stimulates basophils and mast cells for further activation causing allergic inflammation. E-NPP3 decreases ATP concentration and suppresses basophil and mast cell activity.
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