Immune Complexes: Not Just an Innocent Bystander in Chronic Viral Infection

Understanding of how persistent viral infection impacts humoral immunity is incomplete. In this issue of Immunity, Wieland et al. (2015) and Yamada et al. (2015) find that high amounts of IgG-antigen complexes formed during chronic lymphocytic choriomeningitis infection can interfere with Fcg-receptor-mediated effector activities, potentially contributing to immune dysfunction.