期刊
NATURE REVIEWS CANCER
卷 11, 期 8, 页码 609-618出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3105
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资金
- Institut National de la Sante et de la Recherche Medicale (INSERM)
- Ligue Nationale Contre le Cancer
- Fondation de Recherche Medicale (FRM)
- Association pour la Recherche sur le Cancer (ARC)
- Region Nord/Pas-de-Calais
- Universite de Lille 1
In most cases, metastasis, not the primary tumour per se, is the main cause of mortality in cancer patients. In order to effectively escape the tumour, enter the circulation and establish secondary growth in distant organs cancer cells must develop an enhanced propensity to migrate. The ubiquitous second messenger Ca2+ is a crucial regulator of cell migration. Recently, a number of known molecular players in cellular Ca2+ homeostasis, including calcium release-activated calcium channel protein 1 (ORAI1), stromal interaction molecule 1 (STIM1) and transient receptor potential (TRP) channels, have been implicated in tumour cell migration and the metastatic cell phenotype. We discuss how these developments have increased our understanding of the Ca2+ dependence of pro-metastatic behaviours.
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