期刊
PHYSICAL BIOLOGY
卷 8, 期 4, 页码 -出版社
IOP Publishing Ltd
DOI: 10.1088/1478-3975/8/4/045007
关键词
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资金
- Human Frontiers Science Program [RGP-0038]
- NIH Physical Sciences Oncology Centers [U54 CA143862]
- BBSRC [BB/G015082/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/G015082/1] Funding Source: researchfish
Cells and the tissues they form are not passive material bodies. Cells change their behavior in response to external biochemical and biomechanical cues. Behavioral changes, such as morphological deformation, proliferation and migration, are striking in many multicellular processes such as morphogenesis, wound healing and cancer progression. Cell-based modeling of these phenomena requires algorithms that can capture active cell behavior and their emergent tissue-level phenotypes. In this paper, we report on extensions of the subcellular element model to model active biomechanical subcellular processes. These processes lead to emergent cell and tissue level phenotypes at larger scales, including (i) adaptive shape deformations in cells responding to slow stretching, (ii) viscous flow of embryonic tissues, and (iii) streaming patterns of chemotactic cells in epithelial-like sheets. In each case, we connect our simulation results to recent experiments.
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