期刊
JOURNAL OF MEDICAL INVESTIGATION
卷 58, 期 3-4, 页码 197-202出版社
UNIV TOKUSHIMA SCH MEDICINE
DOI: 10.2152/jmi.58.197
关键词
Fourier transform infrared spectroscopy; bone quality; peripheral quantitative computed tomography; three-point bending test
资金
- Grants-in-Aid for Scientific Research [22591658] Funding Source: KAKEN
We studied the changes of biomaterial and biomechanical properties of the rat femur during development. Thirty male Wistar rats were allocated to 6 groups : aged 6 weeks (n=5), 9 weeks (n=5), 12 weeks (n= 5), 15 weeks (n= 5), 24 weeks (n= 5), and 36 weeks (n=5). The mineral to matrix ratio (M/M ratio) of rat femur by Fourier transform infrared spectroscopy was 0.97 +/- 0.10 at the age of 6 weeks, and reached the maximum of 1.52 +/- 0.17 at the age of 36 weeks. Total bone mineral density (BMD) by peripheral quantitative computed tomography of the femoral shaft aged 6 weeks was 479.1 +/- 58.7 mg/cm(3), and reached the maximum of 1022.2 +/- 42.3 mg/cm(3) at the age of 36 weeks. The ultimate load to failure of the femur of the rat aged 6 weeks by the three-point bending test was 29.6 +/- 6.1 N. At the age of 36 weeks, the ultimate load to failure of the rat femur increased to the maximum of 283.5 +/- 14.7 N. The results showed that the M/M ratio increased with development as total BMD and bone strength increased. The results suggest that the M/M ratio is one of the determinants of the biomaterial and biomechanical properties of bone.
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