期刊
JOURNAL OF BIOMOLECULAR SCREENING
卷 16, 期 7, 页码 775-785出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1087057111405851
关键词
SSMD; SSMD*; z score; z* score; t statistic; high-throughput screening
Hit selection is the ultimate goal in many high-throughput screens. Various analytic methods are available for this purpose. Some commonly used ones are z score, z* score, strictly standardized mean difference (SSMD), SSMD*, and t statistic. It is critical to know how to use them correctly because the misusage of them can readily produce misleading results. Here, the author presents basic concepts, elaborates their commonality and difference, describes some common misusage that people should avoid, and uses simulated simple examples to illustrate how to use them correctly. (Journal of Biomolecular Screening 2011;16:775-785)
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