期刊
ANNALS OF BEHAVIORAL MEDICINE
卷 42, 期 1, 页码 120-126出版社
SPRINGER
DOI: 10.1007/s12160-011-9268-y
关键词
HIV; Depression; Adherence; Assessment; Methadone maintenance; HAART
资金
- NCI NIH HHS [P30 CA008748] Funding Source: Medline
- NIDA NIH HHS [R01 DA018603] Funding Source: Medline
Background The impact of measurement methods on the relationship between depression and HIV treatment adherence has not been adequately examined. Purpose The purpose of this paper is to examine the relationship between clinician- and patient-rated depression and HIV medication adherence. Methods The participants were 91 HIV-infected individuals in methadone maintenance. Depression was assessed via clinician ratings (Clinical Global Impression Scale and Montgomery Asberg Depression Rating Scale) and self-report (Beck Depression Inventory-Short Form). Clinicians rated substance abuse using the Clinical Global Impression Scale and a structured interview. HIV medication adherence was measured over the following 2 weeks using electronic caps. Results Each unit increase in the Clinical Global Impression Scale was associated with 75% increased odds of nonadherence (OR = 1.75, p = 0.002, 95% CI = 1.23-2.48). Similarly, for each standard deviation Montgomery Asberg Depression Rating Scale increase, there was a 2.6-fold increased odds of nonadherence (OR = 2.60, p = 0.001, 95% CI = 1.45-4.67). Substance abuse and self-reported depression severity were not significantly related to adherence. Conclusions Clinician-rated depression severity was a strong predictor of nonadherence. Assessment methods may influence the relationship between depression and HIV nonadherence.
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