期刊
ACCOUNTS OF CHEMICAL RESEARCH
卷 44, 期 10, 页码 1061-1070出版社
AMER CHEMICAL SOC
DOI: 10.1021/ar2001777
关键词
-
资金
- National Institutes of Health [EB-00246-18]
- NIH/NCI Center for Oncophysics [CTO PSOC U54-CA-143837]
- National Science Foundation [1033746]
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [1033746] Funding Source: National Science Foundation
For decades, researchers and medical professionals have aspired to develop mechanisms for noninvasive treatment and monitoring of pathological conditions within the human body. The emergence of nanotechnology has spawned new opportunities for novel drug delivery vehicles capable of concomitant detection, monitoring, and localized treatment of specific disease sites. In turn, researchers have endeavored to develop an imaging moiety that could be functionalized to seek out specific diseased conditions and could be monitored with conventional clinical imaging modalities. Such nanoscale detection systems have the potential to increase early detection of pathophysiological conditions because they can detect abnormal cells before they even develop into diseased tissue or tumors. Ideally, once the diseased cells are detected, clinicians would like to treat those cells simultaneously. This Idea led to the concept of multifunctional carriers that could target, detect, and treat diseased cells. The term theranostics has been created to describe this promising area of research that focuses on the combination of diagnostic detection agents with therapeutic drug delivery carriers. Targeted theranostic nanocarriers offer an attractive Improvement to disease treatment because of their ability to execute simultaneous functions at targeted diseased sites. Research efforts in the field of theranostics encompass a broad variety of drug delivery vehicles, imaging contrast agents, and targeting modalities for the development of an all-In-one, localized detection and treatment system. Nanotheranostic systems that utilize metallic or magnetic imaging nanoparticles can also be used as thermal therapeutic systems. This Account explores recent advances in the field of nanotheranostics and the various fundamental components of an effective theranostic carrier.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据