期刊
ACADEMIC RADIOLOGY
卷 15, 期 6, 页码 713-727出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.acra.2008.01.008
关键词
hyperpolarized xenon; Xe-129; lung imaging; surface area per unit volume; S/V; XTC; single breath XTC; SB-XTC; CSSR; T2*; T2
资金
- NCRR NIH HHS [RR14297] Funding Source: Medline
- NHLBI NIH HHS [R01HL073632, R01 HL073632-02, R01 HL073632-04, R01 HL073632, R15HL67784, R01 HL073632-03, R01 HL073632-01] Funding Source: Medline
- NIBIB NIH HHS [EB002553, R01 EB002553] Funding Source: Medline
Rationale and Objectives: Using a novel Xe-129 polarizer with high throughput (1-2 L/hour) and high polarization (similar to 55%), our objective was to demonstrate and characterize human pulmonary applications at 0.2T. Specifically, we investigated the ability of 129Xe to measure the alveolar surface area per unit volume of gas, S-A/V-gas. Materials and Methods: Variable spin echo time (TE) gradient and radiofrequency (RF) echoes were used to obtain estimates of the lung's contribution to both T-2* and T-2. Standard multislice ventilation images were obtained and signal-to-noise ratio (SNR) determined. Whole-lung, time-dependent measurements of Xe-129 diffusion from gas to septal tissue were obtained with a chemical shift saturation recovery (CSSR) method. Four healthy subjects were studied, and the Butler et al CSSR formalism (J Phys Condensed Matter 2002; 14:L297-L304) was used to calculate S-A/V-gas. A single-breath version of the xenon transfer contrast (SB-XTC) method was implemented and used to image Xe-129 diffusion between alveolar gas and septal tissue. A direct comparison of CSSR and SB-XTC was performed. Results: T-2* = 135 +/- 29 ms amd T-2 = 326.2 +/- 9.5 ms. Maximum SNR = 36 for ventilation images from inhalation of IL 86% Xe-129 and voxel volume = 0.225 mL. CSSR analysis showed S-A/V-gas decreased with increasing lung volume in a manner very similar to that observed from histology measurements; however, the absolute value of S-A/V-gas was similar to 40% smaller than histology values. SB-XTC images in different postures demonstrate gravitationally dependent values. Initial comparison of CSSR with XTC showed fairly good agreement with expected ratios. Conclusions: Hyperpolarized Xe-129 human imaging and spectroscopy are very promising methods to provide functional information about the lung.
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