期刊
IET NANOBIOTECHNOLOGY
卷 9, 期 1, 页码 27-34出版社
INST ENGINEERING TECHNOLOGY-IET
DOI: 10.1049/iet-nbt.2013.0067
关键词
nanoparticles; particle size; contact angle; electrokinetic effects; toxicology; cellular biophysics; alumina; silicon compounds; biomedical materials; nanomedicine; SiO2; Al2O3; mass 100 mg; in vitro nanotoxicity; cellular behaviour; radical scavenging percentage; antioxidant properties; NIH 3T3 cell lines; cell viability; silica; alumina; nanometal oxide particles; micrometal oxide particles; biocompatibility; antioxidant activity; in vitro cytotoxicity; biological system; bone replacement materials; implant; tissue engineering; biological applications; nanoparticles; particle size; zeta potential; contact angle
资金
- Defence Research and Development Organisation, New Delhi, India [ERIP/ER/0905113/M/01/1216]
Currently, nanometal oxides find their role in different biological applications such as tissue engineering, implant and bone replacement materials. Owing to the increased use of nanoparticles, it is necessary to understand their release and toxicity in the biological system. In this regard, three independent studies such as in vitro cytotoxicity, antioxidant activity and biocompatibility of nano- and micrometal oxide particles such as alumina (Al2O3) and silica (SiO2) are evaluated. It is evident from cell viability study that nanoAl(2)O(3) and SiO2 particles are less toxic when compared with microAl(2)O(3) and SiO2 to NIH 3T3 cell lines up to 200 mu g/ml. Antioxidant properties of micro- and nanoAl(2)O(3) in terms of radical scavenging percentage for micro- and nanoAl(2)O(3) are 59.1% and 72.1%, respectively, at 100 mg. Similarly, the radical scavenging percentage of nano- and bulk SiO2 are 81.0% and 67.2%, respectively. The present study reveals that the cellular behaviour, interaction and biocompatibility of metal oxides differ with dose, particle size, contact angle and zeta potential. The present study opens up a new strategy to analyse in vitro nanotoxicity.
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