期刊
NATURE REVIEWS CANCER
卷 11, 期 9, 页码 678-684出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3114
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资金
- US National Institutes of Health [R01 DK61671, R01 CA42486, R24 DK084949]
- Patrick C. Walsh Prostate Cancer Research Fund
- [N01-HV-00240]
- [P20RR024214]
O-GlcNAcylation is the covalent attachment of beta-D-N-acetylglucosamine (GlcNAc) sugars to serine or threonine residues of nuclear and cytoplasmic proteins, and it is involved in extensive crosstalk with other post-translational modifications, such as phosphorylation. O-GlcNAcylation is becoming increasing realized as having important roles in cancer-relevant processes, such as cell signalling, transcription, cell division, metabolism and cytoskeletal regulation. However, currently little is known about the specific roles of aberrant O-GlcNAcylation in cancer. In this Opinion article, we summarize the current understanding of O-GlcNAcylation in cancer and its emerging functions in transcriptional regulation at the level of chromatin and transcription factors.
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