期刊
FEMS MICROBIOLOGY REVIEWS
卷 35, 期 5, 页码 790-819出版社
OXFORD UNIV PRESS
DOI: 10.1111/j.1574-6976.2011.00273.x
关键词
Lateral Gene Transfer; antibiotic resistance; mobile genetic elements; nosocomial infection; transposon; integron
类别
资金
- Australian Research Council
- National Health and Medical Research Council of Australia
- University of Technology, Sydney
- Macquarie University
Antibiotics were one of the great discoveries of the 20th century. However, resistance appeared even in the earliest years of the antibiotic era. Antibiotic resistance continues to become worse, despite the ever-increasing resources devoted to combat the problem. One of the most important factors in the development of resistance to antibiotics is the remarkable ability of bacteria to share genetic resources via Lateral Gene Transfer (LGT). LGT occurs on a global scale, such that in theory, any gene in any organism anywhere in the microbial biosphere might be mobilized and spread. With sufficiently strong selection, any gene may spread to a point where it establishes a global presence. From an antibiotic resistance perspective, this means that a resistance phenotype can appear in a diverse range of infections around the globe nearly simultaneously. We discuss the forces and agents that make this LGT possible and argue that the problem of resistance can ultimately only be managed by understanding the problem from a broad ecological and evolutionary perspective. We also argue that human activities are exacerbating the problem by increasing the tempo of LGT and bacterial evolution for many traits that are important to humans.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据