期刊
AAPS PHARMSCITECH
卷 15, 期 4, 页码 1039-1048出版社
SPRINGER
DOI: 10.1208/s12249-014-0134-7
关键词
flowability; fluidized-bed granulation; granule characteristics; high-shear granulation
资金
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Ontario Graduate Scholarship (OGS)
- The University of Western Ontario Graduate Thesis Research Award Fund (GTRAF)
Placebo granules were manufactured by both wet high-shear and fluidized-bed techniques. The granules were compared based on size, shape, surface morphology, and a variety of different flowability measurements. This comparison showed that granule formation and growth were different, with induction growth for high-shear granulation and steady growth for fluidized-bed granulation. Final granules from high-shear granulation were more spherical and dense compared with the irregular granules from fluidized-bed granulation. The high-shear granules demonstrated better overall flow properties.
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