期刊
AAPS PHARMSCITECH
卷 14, 期 4, 页码 1303-1312出版社
SPRINGER
DOI: 10.1208/s12249-013-0023-5
关键词
beta-cyclodextrin; curcumin; diffusion kinetic; hydrophilic gel; nanoparticle; skin permeation
资金
- Indonesia Managing High Education for Relevance and Efficiency Program, Bandung Institute of Technology
Curcumin (CUR) has various pharmacological effects, but its extensive first-pass metabolism and short elimination half-life limit its bioavailability. Therefore, transdermal application has become a potential alternative to delivery CUR. To increase CUR solubility for the development of a transparent homogenous gel and also enhance the permeation rate of CUR into the skin, beta-cyclodextrin-curcumin nanoparticle complex (BCD-CUR-N) was developed. CUR encapsulation efficiency was increased by raising the percentage of CUR to BCD up to 20%. The mean particle size of the best CUR loading formula was 156 nm. All evaluation data using infrared spectroscopy, Raman spectroscopy, powder X-ray diffractometry, differential thermal analysis and scanning electron microscopy confirmed the successful formation of the inclusion complex. BCD-CUR-N increased the CUR dissolution rate of 10-fold (p<0.01). In addition, the improvement of CUR permeability acrossed skin model tissue was observed in gel containing the BCD-CUR-N and was about 1.8-fold when compared with the free CUR gel (p<0.01). Overall, CUR in the form of the BCD-CUR-N improved the solubility further on the penetration of CUR.
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