4.4 Article

Design, Characterization, and In Vitro Evaluation of Antifungal Polymeric Films

期刊

AAPS PHARMSCITECH
卷 14, 期 1, 页码 64-73

出版社

SPRINGER
DOI: 10.1208/s12249-012-9894-0

关键词

anti-fungal activity; drug delivery systems; in vitro models; infrared spectroscopy; thermogravimetric analysis

资金

  1. National University of Rosario (UNR)
  2. National Council Research (CONICET, Argentina)
  3. ANPCyT (Agencia Nacional de Promocion Cientifica y Tecnologica)

向作者/读者索取更多资源

The objective of the present paper was the development and the full characterization of antifungal films. Econazole nitrate (ECN) was loaded in a polymeric matrix formed by chitosan (CH) and carbopol 971NF (CB). Polyethylene glycol 400 and sorbitol were used as plasticizing agents. The mechanical properties of films were poorer when the drug was loaded, probably because crystals of ENC produces network outages and therefore reduces the polymeric interactions between the polymers. Polymers-ECN and CH-CB interactions were analyzed by Fourier-transform infrared spectroscopy (FTIR), thermal gravimetry analysis, and differential thermal analysis (DTA-TGA). ECN did not show structure alterations when loaded into the films. In scanning electron microphotographs and atomic force microscopy analysis, films prepared with CB showed an evident wrinkle pattern probably due to the strong interactions between the polymers, which were observed by FTIR and DTA-TGA. The in vitro activity of the formulations against Candida krusei and Candida parapsilosis was twice as greater as the commercial cream, probably as a result of the antifungal combination of the drug with the CH activity. All these results suggest that these polymeric films containing ECN are potential candidates in view of alternatives dosages forms for the treatment of the yeast assayed.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.4
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据