相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。A GLP-1 Receptor Agonist Conjugated to an Albumin-Binding Domain for Extended Half-Life
Joel Lindgren et al.
BIOPOLYMERS (2014)
Multifaceted Roles of Disulfide Bonds. Peptides as Therapeutics
Miriam Gongora-Benitez et al.
CHEMICAL REVIEWS (2014)
Novel Exenatide Analogs with Peptidic Albumin Binding Domains: Potent Anti-Diabetic Agents with Extended Duration of Action
Odile E. Levy et al.
PLOS ONE (2014)
Pharmacokinetics and metabolism studies on the glucagon-like peptide-1 (GLP-1)-derived metabolite GLP-1(9-36)amide in male Beagle dogs
Heather Eng et al.
XENOBIOTICA (2014)
Once-weekly albiglutide versus once-daily liraglutide in patients with type 2 diabetes inadequately controlled on oral drugs (HARMONY 7): a randomised, open-label, multicentre, non-inferiority phase 3 study
Richard E. Pratley et al.
LANCET DIABETES & ENDOCRINOLOGY (2014)
Improving Binding Affinity and Stability of Peptide Ligands by Substituting Glycines with D-Amino Acids
Shiyu Chen et al.
CHEMBIOCHEM (2013)
The Future of Peptide-based Drugs
David J. Craik et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2013)
Synthesis, Characterization and Pharmacodynamics of Vitamin-B12-Conjugated Glucagon-Like Peptide-1
Susan Clardy-James et al.
CHEMMEDCHEM (2013)
Pharmacokinetics and Pharmacokinetic-Pharmacodynamic Correlations of Therapeutic Peptides
Lei Diao et al.
CLINICAL PHARMACOKINETICS (2013)
Future directions for peptide therapeutics development
Allan A. Kaspar et al.
DRUG DISCOVERY TODAY (2013)
Interspecies Modeling and Prediction of Human Exenatide Pharmacokinetics
Ting Chen et al.
PHARMACEUTICAL RESEARCH (2013)
In Vitro Metabolism of the Glucagon-Like Peptide-1 (GLP-1)-Derived Metabolites GLP-1(9-36)amide and GLP-1(28-36)amide in Mouse and Human Hepatocytes
Raman Sharma et al.
DRUG METABOLISM AND DISPOSITION (2013)
A Perspective on the Prediction of Drug Pharmacokinetics and Disposition in Drug Research and Development
Li Di et al.
DRUG METABOLISM AND DISPOSITION (2013)
Pharmacokinetic predictions for patients with renal impairment: focus on peptides and protein drugs
David Czock et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2012)
Sodium Dependent Multivitamin Transporter (SMVT): A Potential Target for Drug Delivery
Aswani Dutt Vadlapudi et al.
CURRENT DRUG TARGETS (2012)
Peptides As Therapeutics with Enhanced Bioactivity
D. Goodwin et al.
CURRENT MEDICINAL CHEMISTRY (2012)
Cell-penetrating peptides: classes, origin, and current landscape
Francesca Milletti
DRUG DISCOVERY TODAY (2012)
Liraglutide, a long-acting GLP-1 mimetic, and its metabolite attenuate inflammation after intracerebral hemorrhage
Jack Hou et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2012)
Bicyclization and Tethering to Albumin Yields Long-Acting Peptide Antagonists
Alessandro Angelini et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Predicting and Improving the Membrane Permeability of Peptidic Small Molecules
Salma B. Rafi et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Intestinal Permeability of Cyclic Peptides: Common Key Backbone Motifs Identified
Johannes G. Beck et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)
Optimizing PK properties of cyclic peptides: the effect of side chain substitutions on permeability and clearance
Arthur C. Rand et al.
MEDCHEMCOMM (2012)
Strategies in quantitative LC-MS/MS analysis of unstable small molecules in biological matrices
Wenkui Li et al.
BIOMEDICAL CHROMATOGRAPHY (2011)
Effect of Dose Escalation on the In Vivo Oral Absorption and Disposition of Glycylsarcosine in Wild-Type and Pept1 Knockout Mice
Dilara Jappar et al.
DRUG METABOLISM AND DISPOSITION (2011)
Vitamin B-12 in drug delivery: breaking through the barriers to a B-12 bioconjugate pharmaceutical
Susan M. Clardy et al.
EXPERT OPINION ON DRUG DELIVERY (2011)
On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds
Tina R. White et al.
NATURE CHEMICAL BIOLOGY (2011)
Unique challenges of providing bioanalytical support for biological therapeutic pharmacokinetic programs
William L. Nowatzke et al.
BIOANALYSIS (2011)
Intramolecular hydrogen bonding to improve membrane permeability and absorption in beyond rule of five chemical space
Alexander Alex et al.
MEDCHEMCOMM (2011)
The effect of backbone cyclization on PK/PD properties of bioactive peptide-peptoid hybrids: The melanocortin agonist paradigm
Oded Ovadia et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2010)
Hydrophobicity of Peptides Containing D-Amino Acids
Toratane Munegumi
CHEMISTRY & BIODIVERSITY (2010)
Synthetic therapeutic peptides: science and market
Patrick Vlieghe et al.
DRUG DISCOVERY TODAY (2010)
Metabolism and Excretion of the Once-Daily Human Glucagon-Like Peptide-1 Analog Liraglutide in Healthy Male Subjects and Its In Vitro Degradation by Dipeptidyl Peptidase IV and Neutral Endopeptidase
Monika Malm-Erjefalt et al.
DRUG METABOLISM AND DISPOSITION (2010)
Intramolecular Hydrogen Bonding in Medicinal Chemistry
Bernd Kuhn et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Delivery of Therapeutic Proteins
Dipak S. Pisal et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2010)
Design of a Potent D-Peptide HIV-1 Entry Inhibitor with a Strong Barrier to Resistance
Brett D. Welch et al.
JOURNAL OF VIROLOGY (2010)
Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic
Gregory H. Bird et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Strategies to prolong the plasma residence time of peptide drugs
Lisa Pollaro et al.
MEDCHEMCOMM (2010)
Restoration of rat colonic epithelium after in situ intestinal instillation of the absorption promoter, sodium caprate
Xuexuan Wang et al.
THERAPEUTIC DELIVERY (2010)
Evaluation of Strategies for Improving Proteolytic Resistance of Antimicrobial Peptides by Using Variants of EFK17, an Internal Segment of LL-37
Adam A. Stroemstedt et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2009)
Pharmacokinetics of Biotech Drugs: Peptides, Proteins and Monoclonal Antibodies
Jiunn H. Lin
CURRENT DRUG METABOLISM (2009)
Pharmacokinetics and dosage adjustment in patients with renal dysfunction
Roger K. Verbeeck et al.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2009)
Preparation, characterization, and application of biotinylated and biotin-PEGylated glucagon-like peptide-1 analogues for enhanced oral delivery
Su Young Chae et al.
BIOCONJUGATE CHEMISTRY (2008)
Structure-activity relationship and metabolic stability studies of backbone cyclization and N-methylation of melanocortin peptides
Yaniv Linde et al.
BIOPOLYMERS (2008)
An albumin-exendin-4 conjugate engages central and peripheral circuits regulating murine energy and glucose Homeostasis
Laurie L. Baggio et al.
GASTROENTEROLOGY (2008)
Protein and Peptide Drug Delivery: Oral Approaches
Jessy Shaji et al.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2008)
Quantitative bioanalysis of peptides by liquid chromatography coupled to (tandem) mass spectrometry
Irene van den Broek et al.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2008)
Backbone cyclic peptidomimetic melanocortin-4 receptor agonist as a novel orally administrated drug lead for treating obesity
Shmuel Hess et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Alternative stabilities of a proline-rich antibacterial peptide in vitro and in vivo
Paul Bart Noto et al.
PROTEIN SCIENCE (2008)
Safe and effective permeation enhancers for oral drug delivery
Kathryn Whitehead et al.
PHARMACEUTICAL RESEARCH (2008)
Vasopressin and its role in critical care
Andrew Sharman et al.
BJA EDUCATION (2008)
Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide
Federico Bernal et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
Peptide transporter substrate identification during permeability screening in drug discovery: Comparison of transfected MDCK-hPepT1 cells to Caco-2 cells
Praveen. V. Balimane et al.
ARCHIVES OF PHARMACAL RESEARCH (2007)
Non-clinical pharmacology and safety evaluation of TH9507, a human growth hormone-releasing factor analogue
Eckhardt S. Ferdinandi et al.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY (2007)
Therapeutic peptides: technological advances driving peptides into development
Aaron K. Sato et al.
CURRENT OPINION IN BIOTECHNOLOGY (2006)
Innovative approaches to anti-arrhythmic drug therapy
Stanley Nattel et al.
NATURE REVIEWS DRUG DISCOVERY (2006)
Conformational flexibility, internal hydrogen bonding, and passive membrane permeability: Successful in silico prediction of the relative permeabilities of cyclic peptides
Taha Rezai et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)
Is IGnRH-III the most potent GnRH analog containing only natural amino acids that specifically inhibits the growth of human breast cancer cells?
Krisztina Heredi-Szabo et al.
JOURNAL OF PEPTIDE SCIENCE (2006)
Testing the conformational hypothesis of passive membrane permeability using synthetic cyclic peptide diastereomers
T Rezai et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)
Strategies to improve plasma half life time of peptide and protein drugs
M. Werle et al.
AMINO ACIDS (2006)
Comparative genomic analysis of human and chimpanzee proteases
XS Puente et al.
GENOMICS (2005)
The effect of cyclization on the enzymatic degradation of herpes simplex virus glycoprotein D derived epitope peptide
R Tugyi et al.
JOURNAL OF PEPTIDE SCIENCE (2005)
Delineation of human peptide transporter 1 (hPepT1)-mediated uptake and transport of substrates with varying transporter affinities utilizing stably transfected hPepT1/Madin-Darby canine kidney clones and caco-2 cells
RK Bhardwaj et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
Human metabolism of the proteasome inhibitor bortezomib: Identification of circulating metabolites
T Pekol et al.
DRUG METABOLISM AND DISPOSITION (2005)
Partial D-amino acid substitution:: Improved enzymatic stability and preserved Ab recognition of a MUC2 epitope peptide
R Tugyi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
A novel high-throughput PepT1 transporter assay differentiates between substrates and antagonists
Teresa N. Faria et al.
MOLECULAR PHARMACEUTICS (2004)
Relationship between structure and permeability of dipeptide derivatives containing tryptophan and related compounds across human intestinal epithelial (Caco-2) cells
R Ano et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2004)
Relationships between structure and high-throughput screening permeability of peptide derivatives and related compounds with artificial membranes: application to prediction of Caco-2 cell permeability
R Ano et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2004)
Pharmacokinetics and renal excretion of desmopressin after intravenous administration to healthy subjects and renally impaired patients
H Agerso et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2004)
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix
LD Walensky et al.
SCIENCE (2004)
Interspecies scaling of protein drugs: Prediction of clearance from animals to humans
I Mahmood
JOURNAL OF PHARMACEUTICAL SCIENCES (2004)
Phage display-derived peptides as a therapeutic alternatives to antibodies
RC Ladner et al.
DRUG DISCOVERY TODAY (2004)
Phase II study of cetrorelix, a luteinizing hormone-releasing hormone antagonist in patients with platinum-resistant ovarian cancer
CF Verschraegen et al.
GYNECOLOGIC ONCOLOGY (2003)
Large-scale manufacture of peptide therapeutics by chemical synthesis
BL Bray
NATURE REVIEWS DRUG DISCOVERY (2003)
Challenges for the oral delivery of macromolecules
M Goldberg et al.
NATURE REVIEWS DRUG DISCOVERY (2003)
Reversible lipidization for the oral delivery of salmon calcitonin
J Wang et al.
JOURNAL OF CONTROLLED RELEASE (2003)
No entry for TAT(44-57) into liposomes and intact MDCK cells:: novel approach to study membrane permeation of cell-penetrating peptides
SD Krämer et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2003)
The druggable genome
AL Hopkins et al.
NATURE REVIEWS DRUG DISCOVERY (2002)
Characterization of the efflux transporter(s) repsonsible for restricting intestinal mucosa permeation of the coumarinic acid-based cyclic prodrug of the opioid peptide DADLE
FX Tang et al.
PHARMACEUTICAL RESEARCH (2002)
Converting a peptide into a drug: Strategies to improve stability and bioavailability
C Adessi et al.
CURRENT MEDICINAL CHEMISTRY (2002)
Clinical pharmacokinetics of depot leuprorelin
P Periti et al.
CLINICAL PHARMACOKINETICS (2002)
Recognition and oxidative metabolism of cyclodipeptides by hepatic cytochrome P450
M Delaforge et al.
PEPTIDES (2001)
Gastric retention and stability of lipidized Bowman-Birk protease inhibitor in mice
J Wang et al.
INTERNATIONAL JOURNAL OF PHARMACEUTICS (2000)