期刊
AAPS JOURNAL
卷 12, 期 3, 页码 309-317出版社
SPRINGER
DOI: 10.1208/s12248-010-9194-0
关键词
biomarker; cancer; drug discovery; drug target; microRNA
资金
- Ministry of Science and Technology of China [[973]2005CB724605]
- Natural Science Foundation of China [30872930]
- Science and Technology Department of the Zhuhai Municipality of Guangdong Province [PC20071076]
- National Institutes of Health [CA102011, CA130966]
- American Cancer Society (RSG) [CSM-107144]
- Hillman Fellows Program for Innovative Cancer Research
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [UL1TR000005] Funding Source: NIH RePORTER
MicroRNAs (miRNAs), a class of small, regulatory, non-coding RNA molecules, display aberrant expression patterns and functional abnormalities in human diseases including cancers. This review summarizes the abnormally expressed miRNAs in various types of human cancers, possible mechanisms underlying such abnormalities, and miRNA-modulated molecular pathways critical for cancer development. Practical implications of miRNAs as biomarkers, novel drug targets and therapeutic tools for diagnosis, prognosis, and treatments of human cancers are also discussed.
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