期刊
AAPS JOURNAL
卷 12, 期 2, 页码 223-232出版社
SPRINGER
DOI: 10.1208/s12248-010-9181-5
关键词
Cancer stem cells; Drug delivery; Genetic profile; Microenvironment; Pancreatic cancer
资金
- National Cancer Institute, NIH, DHHS [RO1CA100922]
- Eli Lilly Fellowship in pharmacokinetics, pharmacodynamics, and drug metabolism
Pancreatic cancer is the fourth leading cause of cancer-related deaths in the USA. The high mortality rate is partly due to lack of effective treatments. This review summarizes the pathobiology and current treatment options for pancreatic cancer. Moreover, the review discusses the opportunities of developing novel therapies for pancreatic cancer provided by the progress in understanding the genetic mutations, tumor microenvironment, cancer stem cells, and drug delivery.
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