期刊
MOLECULAR CATALYSIS
卷 455, 期 -, 页码 103-107出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mcat.2018.05.029
关键词
Domino reaction; Hydrogen transfer; Cyclization Michael addition; Asymmetric synthesis
资金
- National Nature Science Foundation of China [21672149, 21402120]
- Shanghai Science and Technologies Development Fund [13ZR1458700]
- Shanghai Municipal Education Commission [13CG48]
- Ministry of Education of China [PCSIRT_IRT_16R49]
Tandem catalytic reaction in one-pot possesses remarkable advantages and is a powerful methodology for the synthesis of high value chemicals. Asymmetric transfer hydrogenation catalyzed by Ru-TsDPEN type catalysts, developed Noyori and Ikariya, is a useful strategy for constructing chiral alcohols and amines. Herein, a novel bifunctional Noyori-Ikariya type catalyst was developed, which displays good catalytic efficiency for Michael addition/ATH/cyclization tandem reaction. A series of chiral 3,4-dihydro-2H-pyran-5-carbonitriles were synthesized in good yield (up to 79%) and with excellent enantioselectivity (up to 97%) via this one-pot reaction under mild conditions.
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