期刊
JOURNAL OF BIOMOLECULAR SCREENING
卷 16, 期 8, 页码 878-885出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1087057111413919
关键词
computational chemistry; compound repositories; chemoinformatics; general pharmaceutical process; cardiac diseases
The authors describe a structure-based strategy to identify therapeutically beneficial off-target effects by screening a chemical library of Food and Drug Administration (FDA)-approved small-molecule drugs matching pharmacophores defined for specific target proteins. They applied this strategy to angiotensin-converting enzyme 2 (ACE2), an enzyme that generates vasodilatory peptides and promotes protection from hypertension-associated cardiovascular disease. The conformation-based structural selection method by molecular docking using DOCK allowed them to identify a series of FDA-approved drugs that enhance catalytic efficiency of ACE2 in vitro. These data demonstrate that libraries of approved drugs can be rapidly screened to identify potential side effects due to interactions with specific proteins other than the intended targets. (Journal of Biomolecular Screening 2011;16:878-885)
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