期刊
FRONTIERS IN ONCOLOGY
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2018.00078
关键词
neutrophil-to-lymphocyte; platelet-to-lymphocyte; C-reactive protein; prognosis; cancer; longitudinal; biomarkers
类别
资金
- Big Data Scientist Training Enhance Program (BD-STEP) fellowship
- National Institutes of Health [R01HL101972]
- OHSU/OSU Cancer Prevention and Control Initiative
In this review, we discuss the interaction between cancer and markers of inflammation ( such as levels of inflammatory cells and proteins) in the circulation, and the potential benefits of routinely monitoring these markers in peripheral blood measurement assays. Next, we discuss the prognostic value and limitations of using inflammatory markers such as neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios and C-reactive protein measurements. Furthermore, the review discusses the benefits of combining multiple types of measurements and longitudinal tracking to improve staging and prognosis prediction of patients with cancer, and the ability of novel in silico frameworks to leverage this high-dimensional data.
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