期刊
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
卷 13, 期 6, 页码 527-535出版社
SHENYANG PHARMACEUTICAL UNIV
DOI: 10.1016/j.ajps.2018.02.010
关键词
Disulfiram; Solid dispersion; In-situ gel; Permeability; Anti-cataract
资金
- Liaoning Provincial Key Laboratory of Drug Preparation Design and Evaluation of Liaoning Provincial Education Department [LZ2014045]
To improve the corneal permeability and water-solubility of disulfiram (DSF), which is an ocular drug for cataract, P188 was selected as a matrix to prepare solid dispersion of DSF (DSFSD) by hot melt method. The DSFSD was characterized by DSC, XRD, and IR, and the results suggested that DSF was amorphous in DSFSD. The DSFSD was added to borate buffer solution (BBS) contained 20% poloxamer P407 and 1.2% poloxamer P188 to form in-situ gel. In vitro and in vivo experiments revealed that DSFSD combined with in-situ gel (DSFSD/in-situ gel) increased the residence time and the amount of DSF penetrated through the corneal. The pharmacodynamics studies exhibited DSFSD /in-situ gel delayed the development of selenium-induced cataract at some content. These results investigated that DSFSD/in-situ gel as a drug delivery system can improve DSF ocular permeability. (C) 2018 Shenyang Pharmaceutical University. Published by Elsevier B.V.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据