期刊
SLEEP
卷 41, 期 4, 页码 -出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/sleep/zsy022
关键词
insomnia; reward; hedonia; mood; experience sampling; bright light; circadian rhythm
资金
- Dutch Technology Foundation STW, Netherlands Organization for Scientific Research (NWO) [NeuroSIPE 10738]
- Ministry of Economic Affairs, Agriculture and Innovation
- Light, Cognition, Behaviour and Health (LCBH) project of the National Inititiative Brain and Cognition (NIBC) of the Netherlands Organisation for Scientific Research, The Hague, The Netherlands [058-14-001]
- NeuroTime Erasmus+: Erasmus Mundus programme of the European Commission [520124-1-2011-1-FR-ERA]
- European Research Council of the European Commission [ERC-ADG-2014-671084 INSOMNIA]
Study Objectives: Altered comfort sensing and reduced gray matter volume in the orbitofrontal cortex of the brain in people suffering from insomnia disorder (ID) suggest compromised processes of motivation and hedonia. The experience sampling (ES) method was used to evaluate whether, in naturalistic conditions, people with ID differ from those without sleep complaints with respect to subjective Wanting and Liking, two major dimensions of the reward system. Since light affects brain circuits involved in affect and reward, ES was combined with ambulatory monitoring of light intensity fluctuations to evaluate their effect on subjective Wanting and Liking. Methods: Participants with ID (n = 17, 12 females, 56.8 +/- 6.5 mean +/- standard deviation years of age) and matched controls without sleep complaints (n = 18, 12 females, 57.0 +/- 8.6 years of age) were probed by a smartphone alarm to log their subjective Wanting, Liking, and mood nine times a day for 7 days. Using an ambulatory light recorder, light intensity exposure was sampled simultaneously and averaged over the intervals between subsequent ES alarms. Mixed-effect models were used to evaluate how ID and varying light intensity affected subjective assessments. Results: The results indicated significantly lower subjective Liking and Wanting in people suffering from ID, particularly at low environmental light intensity. Conclusions: Wanting and Liking, rather than more commonly used mood adjectives, showed an increased sensitivity to detect deficient hedonic and reward processing in insomnia during everyday life. Deficient Liking may in part be rescued by exposure to bright environmental light.
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