期刊
ACTA NEUROPATHOLOGICA COMMUNICATIONS
卷 6, 期 -, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/s40478-018-0511-7
关键词
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资金
- German Federal Ministry of Health [IIA5-2512NIK004//321-4471-02]
- Deutsche Forschungsgemeinschaft [SFB/TRR 167, NeuroCure Exc 257, HE 3130/6-1]
- Berlin Institute of Health (BIH)
Seeding and spread of beta-amyloid (A beta) pathologies have been considered to be based on prion-like mechanisms. However, limited transmissibility of A beta seeding activity upon peripheral exposure would represent a key difference to prions, not only in terms of pathogenesis but also in terms of potential transmission of disease. We partially characterized the seeded A beta amyloidosis after intracerebral injection of various brain homogenates in APP/PS1 mice. One particularly seed-laden homogenate was selected to investigate the development of A beta pathologies after intravenous exposure. We report here that a single intravenous injection of an Alzheimer disease patient's-brain extract into APP/PS1 recipient mice led to cerebral amyloid angiopathy within 180 days post injection. Thus, vascular proteinopathies such as CAA are transmissible in mice via the intravenous route of peripheral exposure.
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