期刊
MSYSTEMS
卷 3, 期 2, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/mSystems.00182-17
关键词
bioinformatics; biosynthetic gene cluster; microbiome; natural products; specialized metabolism
类别
资金
- VENI from The Netherlands Organization [863.15.002]
- NWO Groen grant [ALWGR.2015.1]
- NWO Eranet CoBiotech grant [053.80.739]
- NWO-TTW NACTAR grant [16440]
- NWO ASDI grant [ASDI.2017.030]
- Graduate School for Experimental Plant Sciences (EPS), National Institutes of Health Genome [U01GM110706, U101GM110699]
- ZonMW DTL Hotel projects [435003008, 435003011]
Microbial and plant specialized metabolites, also known as natural products, are key mediators of microbe-microbe and host-microbe interactions and constitute a rich resource for drug development. In the past decade, genome mining has emerged as a prominent strategy for natural product discovery. Initially, such mining was performed on the basis of individual microbial genome sequences. Now, these efforts are being scaled up to fully genome-sequenced strain collections, pangenomes of bacterial genera, and large sets of metagenome-assembled genomes from microbial communities. The Medema research group aims to play a leading role in these developments by developing and applying computational approaches to identify, classify, and prioritize specialized metabolite biosynthetic gene clusters and pathways and to connect them to specific molecules and microbiome-associated phenotypes. Moreover, we are extending the scope of genome mining from microbes to plants, which will allow more comprehensive interpretation of the chemical language between hosts and microbes in a microbiome setting.
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