期刊
JOURNAL OF TISSUE ENGINEERING
卷 9, 期 -, 页码 -出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/2041731417751286
关键词
Neuroclusters; migration; microfluidics; photoreceptors; transplantation
资金
- National Institutes of Health [R21 EY026752, SC3 GM113782]
- National Science Foundation [CBET 0939511]
Strategies to replace retinal photoreceptors lost to damage or disease rely upon the migration of replacement cells transplanted into sub-retinal spaces. A significant obstacle to the advancement of cell transplantation for retinal repair is the limited migration of transplanted cells into host retina. In this work, we examine the adhesion and displacement responses of retinal progenitor cells on extracellular matrix substrates found in retina as well as widely used in the design and preparation of transplantable scaffolds. The data illustrate that retinal progenitor cells exhibit unique adhesive and displacement dynamics in response to poly-l-lysine, fibronectin, laminin, hyaluronic acid, and Matrigel. These findings suggest that transplantable biomaterials can be designed to improve cell integration by incorporating extracellular matrix substrates that affect the migratory behaviors of replacement cells.
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